How do I use Systane (polyethylene glycol 400 and propylene glycol) eye drops?

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Last updated: December 19, 2025View editorial policy

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How to Use Systane Eye Drops

For adults and children 6 years and older, instill 1 to 2 drops in the affected eye(s) as needed; children under 6 years should consult a doctor before use. 1

Administration Technique

  • Remove contact lenses before instillation and wait before reinserting them 1
  • Avoid touching the tip of the container to any surface, including the eye, to prevent contamination 1
  • Replace the cap immediately after each use to maintain sterility 1
  • The solution can be used as frequently as needed throughout the day for symptom relief 1

Clinical Application

Systane (polyethylene glycol 400/propylene glycol with hydroxypropyl-guar) is designed for temporary relief of dry eye symptoms including burning, irritation, and discomfort 2, 3. The hydroxypropyl-guar component forms a pH-dependent gel matrix when exposed to the tear film, providing prolonged ocular surface protection and lubrication 4, 5.

For optimal results, instill drops four times daily, though frequency can be adjusted based on symptom severity 4. The formulation's gelling properties enhance retention time on the ocular surface, reducing the need for frequent reapplication compared to traditional artificial tears 5, 6.

Important Safety Warnings

  • Stop use immediately and consult a doctor if you experience eye pain, vision changes, persistent redness or irritation, or if symptoms worsen or persist beyond 72 hours 1
  • Do not use if the solution changes color or becomes cloudy, as this indicates contamination 1
  • Keep out of reach of children; if swallowed, contact a Poison Control Center immediately 1
  • Pregnant or breastfeeding women should consult a healthcare professional before use 1

Common Side Effect

Some users may experience temporary blurred vision immediately after instillation due to the gelling properties of the formulation 4. This typically resolves within minutes as the gel matrix stabilizes on the ocular surface.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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