What is the cause of a painful thenar (thumb) pad?

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Last updated: April 7, 2025View editorial policy

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Differential Diagnosis for Painful Thump Pad

  • Single most likely diagnosis
    • Ulnar nerve entrapment or compression: This condition is a common cause of pain and discomfort in the area of the thump pad, also known as the hypothenar region, due to the proximity of the ulnar nerve.
  • Other Likely diagnoses
    • Ganglion cyst: A benign lump that can develop near joints or tendons, potentially causing pain in the thump pad area if it compresses nearby nerves or causes inflammation.
    • Hypothenar hammer syndrome: A condition characterized by pain and tenderness in the hypothenar region, often due to repetitive trauma or injury to the area, which could affect the thump pad.
    • Callus or blister: Repeated friction or pressure on the thump pad can lead to the formation of calluses or blisters, which can be painful.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Infection (e.g., abscess or cellulitis): Although less common, an infection in the thump pad area can lead to serious complications if not promptly treated, including spread of infection or sepsis.
    • Tumor (benign or malignant): While rare, a tumor in the thump pad area could cause pain and should be considered to ensure early detection and treatment if present.
  • Rare diagnoses
    • Dupuytren's contracture: A condition that affects the palmar fascia, leading to nodules and thickened cords that can cause pain and contracture of the fingers, potentially involving the thump pad area.
    • Glomus tumor: A rare, benign tumor of the glomus body that can occur under the nail or in other parts of the hand, including the thump pad, causing significant pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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