What are the differential diagnoses for shoulder pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 7, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Shoulder Pain

The differential diagnosis for shoulder pain can be organized into the following categories:

  • Single Most Likely Diagnosis
    • Rotator cuff tendinitis: This is the most common cause of shoulder pain, often resulting from repetitive strain or acute injury to the rotator cuff muscles and tendons.
  • Other Likely Diagnoses
    • Adhesive capsulitis (frozen shoulder): Characterized by stiffness and limited range of motion in the shoulder, often following trauma or inflammation.
    • Bursitis: Inflammation of the bursae, fluid-filled sacs that cushion joints and reduce friction, can cause pain and swelling in the shoulder.
    • Osteoarthritis: Wear and tear on the joint cartilage can lead to pain, stiffness, and limited mobility in the shoulder.
    • Labral tears: Tears in the labrum, a cartilage ring surrounding the socket of the shoulder joint, can cause pain and instability.
  • Do Not Miss Diagnoses
    • Septic arthritis: Bacterial infection within the joint can lead to severe pain, swelling, and potential joint destruction if not promptly treated.
    • Fractures: Broken bones in the shoulder region, such as the clavicle, humerus, or scapula, require immediate medical attention.
    • Axillary artery aneurysm or thoracic outlet syndrome: Compression or damage to the blood vessels or nerves in the thoracic outlet can cause severe pain, numbness, and potentially life-threatening complications.
    • Pancoast tumor: A type of lung cancer that can cause shoulder pain due to invasion of the brachial plexus or nearby structures.
  • Rare Diagnoses
    • Rheumatoid arthritis: An autoimmune disorder that can cause inflammation and pain in the shoulder joints, although it is less common than other forms of arthritis.
    • Polymyalgia rheumatica: An inflammatory condition that affects the muscles and joints, often causing pain and stiffness in the shoulders and hips.
    • Osteonecrosis: Death of bone tissue due to lack of blood supply, which can occur in the shoulder joint and cause pain and limited mobility.
    • Sickle cell disease: A genetic disorder that can cause bone pain, including in the shoulders, due to vaso-occlusive crises.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.