Differential Diagnosis for Elevated Monocytes, Eosinophils, and Platelets in a Child with Chronic Abdominal Pain
- Single Most Likely Diagnosis
- Inflammatory bowel disease (IBD): This condition, which includes Crohn's disease and ulcerative colitis, often presents with chronic abdominal pain, diarrhea, weight loss, and can cause elevations in monocytes, eosinophils, and platelets due to the ongoing inflammatory process.
- Other Likely Diagnoses
- Parasitic infection: Certain parasites, such as giardiasis or strongyloidiasis, can cause chronic abdominal pain and elevate eosinophil counts. Monocytosis and thrombocytosis may also occur due to the body's inflammatory response.
- Allergic disorders: Conditions like eosinophilic gastroenteritis can present with abdominal pain and elevated eosinophils. Monocytes and platelets may also be elevated in response to the allergic inflammation.
- Chronic infections: Chronic infections such as tuberculosis or chronic bacterial infections can cause elevations in monocytes and platelets, along with abdominal pain.
- Do Not Miss Diagnoses
- Malignancy: Although rare in children, malignancies like leukemia or lymphoma can cause elevations in monocytes, eosinophils, and platelets, along with abdominal pain due to organ involvement.
- Vasculitis: Conditions like Henoch-Schönlein purpura or polyarteritis nodosa can cause abdominal pain, elevated inflammatory markers, and affect various blood cell lines.
- Rare Diagnoses
- Mastocytosis: A condition characterized by the accumulation of mast cells in various tissues, which can cause abdominal pain, diarrhea, and elevations in eosinophils and other blood cell types.
- Eosinophilic leukemia: A rare condition that can cause marked elevations in eosinophils, along with other blood cell abnormalities and abdominal pain due to organ involvement.
- Storage diseases: Certain storage diseases, such as Gaucher's disease, can cause abdominal pain, hepatosplenomegaly, and elevations in various blood cell types due to the accumulation of toxic substances.