From the Guidelines
Ceftazidime-avibactam should be dosed at 2.5 grams (2 grams ceftazidime plus 0.5 grams avibactam) administered intravenously every 8 hours for patients with normal renal function, as recommended by the most recent guidelines 1. The infusion should be given over 2 hours. Dosage adjustments are required for patients with impaired kidney function.
- For creatinine clearance 31-50 mL/min, reduce to 1.25 grams every 8 hours
- For 16-30 mL/min, give 0.94 grams every 12 hours
- For 6-15 mL/min, administer 0.94 grams every 24 hours
- And for patients on hemodialysis, give 0.94 grams every 48 hours. Treatment duration typically ranges from 5 to 14 days depending on the site and severity of infection, as outlined in the guidelines for the treatment of infections due to multidrug-resistant organisms 1. This antibiotic combination is effective against many multidrug-resistant gram-negative bacteria, including those producing extended-spectrum beta-lactamases (ESBLs) and some carbapenemases, making it a valuable option for the treatment of complex infections 1. The avibactam component is a beta-lactamase inhibitor that protects ceftazidime from degradation by certain bacterial enzymes, extending its spectrum of activity against resistant organisms. It is essential to note that the treatment duration and dosage may need to be individualized based on the patient's response to therapy, underlying comorbidities, and infection site, as emphasized in the guidelines 1.
From the FDA Drug Label
The Cmax and AUC of ceftazidime increase in proportion to dose Avibactam demonstrated approximately linear pharmacokinetics across the dose range studied (50 mg to 2000 mg) for single intravenous administration. AVYCAZ 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) AVYCAZ 2.5 grams (ceftazidime and avibactam) for injection is supplied as a white to yellow sterile powder for constitution in a single-dose, sterile, clear glass vial containing ceftazidime 2 grams (equivalent to 2.635 grams of ceftazidime pentahydrate/sodium carbonate powder) and avibactam 0.5 grams (equivalent to 0.551 grams of avibactam sodium).
The recommended dosage of ceftazidime avibactam is 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) administered every 8 hours as a 2-hour infusion 2.
- Ceftazidime: 2 grams
- Avibactam: 0.5 grams The dosage form and strength of AVYCAZ is 2.5 grams (ceftazidime and avibactam) for injection 2.
From the Research
Ceftazidime-Avibactam Dosage
- The recommended dosage of ceftazidime-avibactam is 2000 mg/500 mg every 8 hours, with doses adjusted for renal function 3.
- For severe infection patients with normal renal function and augmented renal clearance, the infusion duration may need to be extended to 3 hours and 4 hours to achieve the targets of 100%fT ≥ MIC and 100%fT ≥ CT=1.0 mg/L 4.
- Continuous infusion at higher dosages may be necessary to achieve 100%fT ≥ 4×MIC and 100%fT ≥ CT=4.0 mg/L targets 4.
- The dosage of ceftazidime-avibactam can be adjusted based on the patient's renal function, with a recommended dose of 500 mg/125 mg every 8 hours for patients with renal impairment 5.
Specific Patient Populations
- For patients with complicated urinary tract infections, including acute pyelonephritis, the recommended dosage is 2000 mg/500 mg every 8 hours 3, 6.
- For patients with hospital-acquired pneumonia, including ventilator-associated pneumonia, the recommended dosage is 2000 mg/500 mg every 8 hours 7.
- For patients with complicated intra-abdominal infections, the recommended dosage is 2000 mg/500 mg every 8 hours 7.