From the Guidelines
Mannitol infusion is not directly associated with causing fever as a side effect, and any fever that occurs should be investigated for other underlying causes. According to the study published in Pediatrics in 2008 1, the potential side effects of mannitol infusion include apnea, hyperthermia, and seizures, but these are not reasons to stop the infusion. However, it's essential to note that hyperthermia is mentioned, which could be related to fever, but it is not explicitly stated as a common side effect. Some key points to consider when administering mannitol infusion include:
- Monitoring for potential side effects such as apnea, hyperthermia, and seizures
- Providing respiratory support if necessary
- Investigating other causes of fever, such as infection, inflammation, or reactions to concurrent medications, if it occurs during mannitol therapy. Mannitol is an osmotic diuretic used to reduce intracranial pressure, treat cerebral edema, and manage acute kidney injury, and its administration requires careful monitoring of vital signs, fluid balance, electrolytes, and renal function.
From the Research
Mannitol Infusion and Fever
- There is no direct evidence in the provided studies that mannitol infusion causes fever 2, 3, 4, 5, 6.
- The studies primarily focus on the effects of mannitol on intracranial pressure, cerebral edema, and brain injury, without mentioning fever as a side effect.
- The potential side effects of mannitol mentioned in the studies include hypotension 5, hyperosmolar states, and rebound phenomenon, but fever is not listed.
- It is possible that fever may be a rare or indirect side effect of mannitol infusion, but there is no conclusive evidence to support this claim based on the provided studies.