From the FDA Drug Label
Warnings For external use only Do not use more than directed unless told to do so by a doctor do not put directly into the rectum by using fingers or any mechanical device or applicator Stop use and ask a doctor if condition worsens, symptoms persist for more than 7 days or clear up and occur again within a few days, and do not begin use of any other hydrocortisone product unless you have asked a doctor rectal bleeding occurs
The Anusol 2.5% product contains hydrocortisone.
- The product is for external use only.
- It should not be inserted into the rectum.
- If rectal bleeding occurs, the user should stop use and ask a doctor. 1
From the Research
Anusol 2.5% HC is not the most effective treatment option for hemorrhoids, as recent studies suggest that lidocaine 5% ointment may be more effective in relieving pain, itching, and discomfort associated with hemorrhoids, as shown in a study published in 2025 2.
Treatment Options
When considering treatment options for hemorrhoids, it's essential to prioritize morbidity, mortality, and quality of life.
- For external hemorrhoids, applying a small amount of lidocaine 5% ointment to the affected area up to 3-4 times daily, especially after bowel movements, may be a more effective treatment option.
- For internal hemorrhoids, using an applicator to insert the lidocaine 5% ointment rectally may provide relief from symptoms.
- Lifestyle modifications, such as increased fiber intake, adequate hydration, and avoiding straining during bowel movements, can complement treatment and help prevent recurrence.
Side Effects and Precautions
- Side effects of lidocaine 5% ointment may include local irritation, burning, or rarely, systemic absorption with prolonged use.
- If symptoms worsen or don't improve within a week, it's crucial to consult a healthcare provider.
Recent Studies
A recent study published in 2025 2 found that lidocaine 5% ointment was effective in relieving pain, itching, and discomfort associated with hemorrhoids, with no adverse effects reported.
- This study suggests that lidocaine 5% ointment may be a more effective treatment option for hemorrhoids compared to other treatments, including Anusol 2.5% HC.
- Another study published in 2021 3 found that Hemoheal cream, an anti-hemorrhoid herbal preparation, was effective in improving clinical signs and symptoms in patients with hemorrhoids, but it's essential to note that this study had a smaller sample size and was not directly comparable to the study on lidocaine 5% ointment.