From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Amlodipine 15mg is a higher than standard dose for this calcium channel blocker medication, and patients should consult with their healthcare provider immediately to discuss potential risks and alternative treatment options. The typical maximum recommended daily dose of amlodipine is 10mg, making 15mg exceed standard dosing guidelines 1. Amlodipine is commonly prescribed for hypertension (high blood pressure) and certain types of chest pain (angina), working by relaxing blood vessels to improve blood flow.
Key Points to Consider
- When exceeding recommended doses, patients may experience increased side effects including severe dizziness, lightheadedness, excessive lowering of blood pressure, peripheral edema (swelling in the legs/ankles), and reflex tachycardia (increased heart rate) 2.
- Some patients with resistant hypertension may occasionally be prescribed higher doses under close medical supervision, but this is not common practice and requires careful monitoring 3.
- If you're experiencing inadequate blood pressure control on standard doses, your doctor might consider adding a second medication rather than exceeding the maximum recommended dose of amlodipine 4.
- Amlodipine has a low renal clearance and long half-life, which allows it to sustain its anti-hypertensive effect for more than 24 hours following a single dose 1.
Recommendations
- Patients taking amlodipine 15mg should consult with their healthcare provider to discuss potential risks and alternative treatment options.
- Healthcare providers should consider adding a second medication rather than exceeding the maximum recommended dose of amlodipine for patients with inadequate blood pressure control.
- Close medical supervision is necessary for patients taking higher doses of amlodipine, especially those with resistant hypertension.