What is the pathophysiology of Thoracic Outlet Syndrome (TOS)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 8, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Thoracic outlet syndrome (TOS) is a condition where blood vessels or nerves in the space between your collarbone and first rib (thoracic outlet) become compressed, causing pain in your shoulders and neck and numbness in your fingers, and the most effective approach to managing TOS involves a combination of physical therapy, pain management, and lifestyle modifications, with surgery reserved for severe cases that do not respond to conservative treatment 1.

Understanding Thoracic Outlet Syndrome

TOS can be classified into three main types: neurogenic (affecting nerves), venous (affecting veins), and arterial (affecting arteries), with neurogenic being the most common. Symptoms typically include:

  • Pain, numbness, tingling in the neck, shoulder, arm or hand
  • Weakness in the hand
  • Discoloration or swelling in the arm TOS is often caused by physical trauma, repetitive arm or shoulder movements, anatomical abnormalities like an extra rib, or poor posture.

Diagnosis and Treatment

Diagnosis involves physical examination, imaging tests like X-rays or MRIs, and nerve conduction studies. Treatment usually begins conservatively with:

  • Physical therapy to strengthen chest muscles and improve posture
  • Pain medication like NSAIDs
  • Activity modifications For severe cases not responding to conservative treatment, surgery may be necessary to remove the first rib or repair compressed blood vessels 1. Prevention strategies include:
  • Maintaining good posture
  • Taking breaks during repetitive activities
  • Strengthening shoulder muscles
  • Avoiding carrying heavy bags on your shoulders

Imaging and Radiological Evaluation

Imaging tests such as CT, MRI, and ultrasound can be used to evaluate the thoracic outlet and diagnose TOS. MRI is typically performed with high-resolution T1-weighted and T2-weighted sequences in sagittal and axial planes to delineate anatomy and evaluate cervical radiculopathy, the brachial plexus, muscular attachments, and sites of compression 1. CT evaluation of TOS is typically performed in “neutral” and “stressed” positions, with images obtained from the elbow to aortic arch with the arms adducted (neutral), followed by abduction (stressed) and repeat imaging 1.

From the Research

Definition and Classification of Thoracic Outlet Syndrome

  • Thoracic outlet syndrome (TOS) is a condition caused by compression of the neurovascular structures leading to the arm passing through the thoracic outlet 2.
  • TOS can be classified as neurogenic, arterial, or venous based on the compressed structure(s) 3.
  • Neurogenic TOS is the most common type, accounting for 95% of cases, while venous and arterial TOS account for 4-5% and 1% of cases, respectively 2.

Causes and Risk Factors

  • TOS can be caused by congenital abnormalities, such as cervical ribs or fibrous bands originating from a cervical rib 3.
  • Neck trauma or repeated work stress can cause scalene muscle scaring or dislodging of a congenital cervical rib, leading to compression of the brachial plexus 3.
  • Anatomical variations, such as hypertrophy of the neck musculature, can also contribute to TOS 4.
  • Other risk factors include abrupt movements, edema, pregnancy, repeated overhead motions, and abnormal posture 4.

Symptoms and Diagnosis

  • Patients with TOS typically experience upper limb pain, numbness, tingling, or weakness that is exacerbated by shoulder or neck movement 4.
  • Diagnosis of TOS can be established through history, physical examination maneuvers, and imaging 3.
  • Diagnostic tests may include duplex ultrasonography to detect thrombosis in arterial or venous TOS 2.

Treatment Options

  • Conservative management of TOS includes postural correction, stretching exercises, and strengthening exercises of the lower scapular stabilizers 5, 6.
  • Nonsurgical treatment may also include anti-inflammatory medication, weight loss, physical therapy, and botulinum toxin injections 3.
  • Surgical treatment options include brachial plexus decompression, neurolysis, and scalenotomy with or without first rib resection 3, 2.
  • A multidisciplinary approach is recommended for proper treatment of TOS, regardless of the type encountered 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Current management of thoracic outlet syndrome.

Current treatment options in cardiovascular medicine, 2009

Research

Thoracic outlet syndrome: a review.

Journal of shoulder and elbow surgery, 2022

Research

Conservative management of thoracic outlet syndrome.

Seminars in thoracic and cardiovascular surgery, 1996

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.