What are the recommended doses of Metronidazole and Ofloxacin for a 2-year-old boy weighing 12 kilograms?

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From the Research

Recommended Doses

  • The recommended dose of Ofloxacin for a 2-year-old boy weighing 12 kilograms is 15 to 20 mg/kg of body weight 1.
  • The recommended dose of Metronidazole is not explicitly stated in the provided studies for a 2-year-old boy weighing 12 kilograms.

Pharmacokinetics and Safety

  • Ofloxacin was safe and well tolerated in children with MDR-TB, but exposures were well below reported adult values, suggesting that dosage modification may be required to optimize MDR-TB treatment regimens in children 1.
  • Metronidazole at 500 mg q8h or 1,500 mg q24h resulted in similar AUIC(0-24) and AUBC(0-24) values, and all combination regimens of levofloxacin and metronidazole were well tolerated, and no serious drug-related adverse effects were reported 2.

Dosing Schedules

  • A 12-hourly dose interval of metronidazole is no different from an 8-hourly dose interval, in prevention of local wound infection following minor oral surgery 3.
  • A once-daily regimen of levofloxacin plus metronidazole looks promising for the treatment of intra-abdominal infections 4.

In Vitro Activity

  • The combination of metronidazole plus ofloxacin had an additive bacteriostatic effect or a synergistic effect against anaerobic strains, and no antagonism was noted with any strain 5.

References

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