What is the estimated blood volume in milliliters per kilogram (ml/kg) or cubic centimeters per kilogram (cc/kg) for a 2-year-old girl?

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Estimated Blood Volume for a 2-Year-Old Girl

The estimated blood volume for a 2-year-old girl is 75 cc/kg (or mL/kg). 1, 2

Age-Specific Blood Volume Estimates

A 2-year-old child falls into the pediatric age category of 2-11 years, which has a standardized blood volume estimate of 75 mL/kg according to current guidelines. 1, 2

Developmental Context

  • Older infants (0.5-2 years) have an estimated blood volume of 75-80 mL/kg, representing the transition period. 1, 2

  • Children (2-11 years) have a more stable estimate of approximately 75 mL/kg, which your 2-year-old patient has just entered. 1, 2

  • This represents a physiologic decrease from the neonatal period, when blood volume is highest at 85-100 mL/kg. 2

Clinical Application

Calculating Total Blood Volume

For a typical 2-year-old girl weighing approximately 12 kg:

  • Total blood volume = 12 kg × 75 mL/kg = 900 mL 1

Blood Product Dosing Based on This Estimate

  • RBC transfusion: 10 mL/kg increases hemoglobin by approximately 20 g/L 2, 3
  • Fresh frozen plasma: 10-15 mL/kg 2, 3
  • Platelets: 10-20 mL/kg 2, 3
  • Cryoprecipitate: 5-10 mL/kg 2, 3

Important Clinical Caveats

The 75 mL/kg estimate is a guideline that does not account for individual variation. 2

Factors affecting actual blood volume include:

  • Hydration status - dehydration decreases effective blood volume 2
  • Underlying medical conditions - chronic diseases may alter blood volume 2
  • Body composition variations - adiposity affects the mL/kg calculation 2

Safe Blood Draw Considerations

  • Always use weight-based calculations rather than age-based estimates alone when calculating safe blood draw volumes or assessing hemorrhage severity. 2

  • Only 2% of children up to 3 years old should have a blood volume draw exceeding 1 mL/kg body weight. 4

  • Each percentage of blood volume lost represents a more significant physiologic insult in smaller children due to their smaller absolute blood volumes. 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Estimating Pediatric Blood Volume

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Management of Neonatal Bleeding

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Blood loss from laboratory diagnostic tests in children.

Clinical chemistry and laboratory medicine, 2013

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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