From the Guidelines
Semaglutide dose spacing should be every 4 weeks, with gradual dose titration starting at 0.25 mg weekly for the first 4 weeks, followed by doses of 0.5 mg, 1.0 mg, and 1.7 mg weekly every 4 weeks at each dose, until the maintenance dose of 2.4 mg is reached after 16 weeks. This dosing schedule is based on the most recent and highest quality study, which recommends gradual dose titration to minimize the risk of GI adverse effects 1. The study, published in 2022 in the journal Gastroenterology, provides guidance on the use of glucagon-like peptide 1 receptor agonists, including semaglutide and liraglutide.
Key Considerations
- Gradual dose titration is recommended to minimize the risk of GI adverse effects
- The dose spacing for semaglutide is every 4 weeks, with the following doses: 0.25 mg, 0.5 mg, 1.0 mg, and 1.7 mg weekly, until the maintenance dose of 2.4 mg is reached after 16 weeks
- Clinical judgment is recommended for adjusting the titration schedule as needed for an individual patient’s response, tolerance, and adverse effects
- If more than 2 consecutive doses are missed, clinical judgment is required to decide on subsequent dosing, with the option to resume at the same dose or lower the next dose, or restart the titration schedule if 3 or more consecutive doses are missed 1.
Dosing Schedule
- Start with 0.25 mg weekly for the first 4 weeks
- Increase to 0.5 mg weekly for the next 4 weeks
- Increase to 1.0 mg weekly for the next 4 weeks
- Increase to 1.7 mg weekly for the next 4 weeks
- Reach the maintenance dose of 2.4 mg after 16 weeks This dosing schedule is designed to achieve therapeutic levels of the medication in the body while minimizing the risk of adverse effects. Patients should maintain consistent timing between doses for optimal therapeutic effect, and any missed doses should be administered as soon as possible, with the regular schedule resumed thereafter.
From the Research
Glimpse Dose Spacing
There are no research papers to assist in answering this question, as none of the provided studies directly address the topic of "glimpse dose spacing". The studies cover a range of topics, including:
- Peritoneal carcinomatosis in nongynecologic malignancy 2
- The immune response during sepsis 3
- Promotion of hair growth by ginseng radix 4
- Macrophage peroxisomes and alveolar regeneration after viral infection 5
- Polysome decay in Escherichia coli during amino acid starvation 6 Key points from these studies include:
- The presence of ascites is associated with poor survival in patients with peritoneal carcinomatosis 2
- Immunossuppression is a major contributor to sepsis 3
- Ginseng radix has hair growth promoting activity 4
- Macrophage peroxisomes play a crucial role in inflammation resolution and lung repair 5
- Amino acid starvation affects polysome decay in Escherichia coli 6