What is the Wixela (fluticasone-salmeterol) 250-50 dose frequency per day for asthma patients?

From the Guidelines

Wixela Inhub 250-50 should be taken as one inhalation twice daily for asthma management, as this frequency is consistent with the use of combination LABA/ICS medications like fluticasone and salmeterol, which are inhaled twice daily 1. This means patients should use the inhaler once in the morning and once in the evening, approximately 12 hours apart.

• Each dose delivers a combination of 250 mcg of fluticasone propionate (an inhaled corticosteroid) and 50 mcg of salmeterol (a long-acting beta-agonist).
• This combination works by reducing inflammation in the airways while also providing long-acting bronchodilation to keep airways open, as outlined in the management of asthma with combination medications 1. It's essential to follow the prescribed regimen and not use Wixela for acute asthma attacks, as it is not a rescue medication.
• If asthma symptoms worsen or if rescue inhalers are needed more frequently than usual, medical attention should be sought promptly.
• The medication should be used regularly as prescribed, even when feeling well, to maintain optimal asthma control, in line with guidelines for the long-term management of asthma 1.

From the Research

Wixela Dose 250-50 Frequency per Day for Asthma Patients

• The Wixela Inhub device is a generic equivalent of Advair Diskus, a fixed-dose combination of fluticasone propionate/salmeterol powder for oral inhalation for patients with asthma whose symptoms are not controlled with inhaled corticosteroids alone 2.
• The recommended dose of Wixela Inhub for asthma patients is not explicitly stated in the provided studies, but the bioequivalence of Wixela Inhub and Advair Diskus has been demonstrated in several studies 2, 3.
• A study comparing the efficacy and tolerability of once-daily salmeterol/fluticasone propionate combination (SFC) with once-daily fluticasone propionate (FP) in patients with mild persistent asthma found that SFC 50 microg/100 microg provided significantly greater improvements in lung function and asthma symptoms than FP 100 microg alone 4.
• Another study found that initiation of maintenance therapy with salmeterol and fluticasone propionate in patients with asthma treated with short-acting beta2-agonists alone provides greater improvements in pulmonary function and symptom control than initiation of maintenance therapy with fluticasone propionate alone 5.
• The frequency of administration for Wixela Inhub is typically twice daily, as demonstrated in a study comparing the local therapeutic equivalence of Wixela Inhub and Advair Diskus in adults with asthma 3.
• The dose of 250-50 microg of Wixela Inhub is likely referring to the 250 microg fluticasone propionate and 50 microg salmeterol dose, which is a common dosage for asthma patients 2, 3.
• However, the exact frequency per day for this specific dose is not explicitly stated in the provided studies.