Maximum Dose of Robaxin (Methocarbamol)
The maximum recommended dose of Robaxin (methocarbamol) is 8 grams per day for severe conditions during the first 48-72 hours of treatment, after which the dose should be reduced to approximately 4 grams per day for maintenance. 1
Initial Dosing Strategy
- For the first 48-72 hours: 6 grams per day is the standard recommended dose for acute muscle spasm 1
- For severe conditions only: Up to 8 grams per day may be administered during this initial period 1
- This aggressive initial approach targets the acute phase of painful muscle spasm when symptoms are most severe 1
Maintenance Dosing
- After the initial 48-72 hours: Reduce to approximately 4 grams per day 1
- This maintenance dose balances efficacy with safety for longer-term use 1
Practical Dosing Regimens
For 500 mg tablets 1:
- Initial: 3 tablets four times daily (6 grams/day)
- Maintenance: 2 tablets four times daily (4 grams/day)
For 750 mg tablets 1:
- Initial: 2 tablets four times daily (6 grams/day)
- Maintenance: 1 tablet every 4 hours OR 2 tablets three times daily (4 grams/day)
Critical Safety Considerations
- Never exceed 8 grams per day, even in severe cases, as this represents the absolute maximum dose 1
- Limit the 8-gram dose to 48-72 hours maximum to minimize risk of adverse effects 1
- Methocarbamol has sedative properties that can cause CNS depression, particularly when combined with alcohol or other CNS depressants 2
- The drug demonstrated efficacy at 6 grams per day (1500 mg four times daily) in approximately 60% of patients with painful muscle spasm 3