From the Guidelines
There is no difference between generic Vyvanse and lisdexamfetamine because lisdexamfetamine is the generic name for Vyvanse. Vyvanse is simply the brand name version of the medication lisdexamfetamine dimesylate. Both contain the same active ingredient and work the same way in the body. Lisdexamfetamine is a prodrug, meaning it remains inactive until metabolized in the body, where it converts to dextroamphetamine, the active compound that treats conditions like ADHD and binge eating disorder. This prodrug formulation gives it a gradual onset and longer duration of action compared to immediate-release stimulants.
Key Points to Consider
- Generic versions of lisdexamfetamine became available in the United States in August 2023 after Vyvanse's patent expired, as noted in recent medical updates 1.
- These generic versions contain the identical active ingredient and are required by the FDA to be bioequivalent to the brand name medication, though they may differ in inactive ingredients, appearance, and cost.
- Patients should note that insurance coverage often favors generic medications due to their lower cost.
- The dosing recommendations for lisdexamfetamine, as outlined in the study 1, suggest a usual starting dose of 20-30 mg po qam, with titration by 10 mg weekly to a maximum of 70 mg daily.
- It is essential to consider the potential risks associated with lisdexamfetamine, including limited published information on its use in pregnancy and breastfeeding, as highlighted in the study 1.
From the Research
Difference between Generic Vyvanse and Lisdexamfetamine
- Lisdexamfetamine is the active ingredient in Vyvanse, which is a brand-name medication 2.
- Generic Vyvanse, on the other hand, refers to a generic version of the medication that contains the same active ingredient, lisdexamfetamine, but is manufactured by a different company.
- The main difference between generic Vyvanse and lisdexamfetamine is the manufacturer and the price, as generic medications are often cheaper than brand-name medications 3, 4.
Mechanism of Action
- Lisdexamfetamine is a prodrug that is converted into its active form, d-amphetamine, in the body 2, 5.
- D-amphetamine acts as a central nervous system stimulant, increasing the levels of dopamine and norepinephrine in the brain 4, 6.
- The mechanism of action of generic Vyvanse is the same as that of lisdexamfetamine, as it contains the same active ingredient.
Efficacy and Safety
- Lisdexamfetamine has been shown to be effective in the treatment of attention-deficit hyperactivity disorder (ADHD) and binge eating disorder (BED) 2, 3, 5.
- Generic Vyvanse has also been shown to be effective in the treatment of ADHD and BED, with a similar efficacy and safety profile to lisdexamfetamine 4, 6.
- Common side effects of lisdexamfetamine and generic Vyvanse include dry mouth, insomnia, and headache 3, 5.