What is the evidence for trastuzumab deruxtecan (trastuzumab deruxtecan) or T-DM1 (ado-trastuzumab emtansine) after progression on lapatinib (lapatinib) for metastatic (mets) breast cancer that is HER2-positive?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board

Educational purpose only • Exercise caution as content is pending human review

Article Review Status

Submitted

Under Review

Approved

Last updated: December 23, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What is the recommended number of cycles of Emhertu (trastuzumab deruxtecan) for a patient with metastatic invasive ductal carcinoma (IDC) being considered for third-line treatment?

Can Trastuzumab Emtansine (T-DM1) be given to a patient with HER2-positive metastatic breast cancer and a history of interstitial lung disease?

What is the role of trastuzumab deruxtecan (trastuzumab deruxtecan) in the treatment of patients with HER2-positive metastatic breast cancer, particularly those who have received prior treatments including trastuzumab and pertuzumab?

What is the Destiny Breast 11 trial for adult females with HER2-positive metastatic breast cancer who have received prior treatments?

What is a viable treatment option for a patient with HER2-positive metastatic breast cancer, considering the Destiny Breast 5 trial results?

What is the recommended dose of Spironolactone (Lasilactone) for pediatric patients with Chronic Liver Disease?

What is the recommended treatment for a 1-year-old asymptomatic child with a cystic hygroma (cystic lymphangioma) presenting as a large right neck mass?

What is the treatment for non-asthmatic eosinophilic bronchitis?

What is the maximum dose (MD) in adults for oral cefuroxime (Cefuroxime axetil) 250 mg/5 ml?

Does dehydration cause hypotension (low blood pressure) or hypertension (high blood pressure)?

What is the best blood pressure medication for a 68-year-old black male with refractory hypertension (high blood pressure) and left ventricular hypertrophy (LVH) already on carvedilol (beta blocker) 25mg twice daily, losartan (angiotensin II receptor antagonist) 100mg, and nifedipine (calcium channel blocker) 90mg?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.