Neomycin Ophthalmic Dosing
I cannot provide a recommendation for neomycin ophthalmic dosing because the evidence provided does not contain any guidelines, drug labels, or research specifically addressing neomycin ophthalmic solution dosing for eye infections.
Critical Evidence Gap
The evidence presented consists entirely of:
- Rodent microbiota depletion protocols using oral/gavage neomycin at concentrations of 0.01-1 g/L in drinking water for research purposes 1
- Oral decolonization regimens for multidrug-resistant bacteria using neomycin sulphate 80-250 mg orally four times daily 1, 2
- Combination ophthalmic products containing neomycin (e.g., Maxitrol with neomycin 3500 IU/mL + polymyxin B + dexamethasone) 3, 4
- Otic (ear) preparations with neomycin for otitis externa 5
- Neonatal prophylaxis using erythromycin 0.5% ointment, not neomycin 1
What the Evidence Actually Shows
For combination ophthalmic products containing neomycin:
- Maxitrol (neomycin 3500 IU/mL + polymyxin B 6000 IU/mL + dexamethasone 0.1%) was studied as 1 drop four times daily for bacterial blepharitis/conjunctivitis 3
- However, the study specifically noted "the well-known toxic problems of neomycin sulphate have to be taken into account" for long-term use 3
Critical safety concern:
- Neomycin allergy manifests as contact dermatitis 48-96 hours after exposure 6
- Neomycin carries ototoxicity risk when used in ear preparations 5
Clinical Recommendation
You should consult the FDA-approved drug label for the specific neomycin ophthalmic product you intend to use, as dosing varies by formulation and indication. The evidence provided does not support making a dosing recommendation for neomycin ophthalmic solution as a standalone agent.