Can You Split Synjardy Tablets?
No, you should not split Synjardy tablets. The FDA-approved prescribing information explicitly states that Synjardy tablets must be "swallowed whole" and instructs patients to "not split, crush, dissolve, or chew" the tablets 1.
Why Splitting Is Not Recommended
Pharmaceutical Formulation Issues
Synjardy contains two active ingredients (empagliflozin and metformin) that are combined in a fixed-dose formulation designed for intact administration 1.
The tablet coating and matrix are engineered to deliver both medications appropriately when swallowed whole 1.
Splitting destroys the tablet integrity, which can impair both the safety and effectiveness of the medication, particularly for formulations with specific release characteristics 2.
Clinical Evidence Against Tablet Splitting
Approximately 10% of split tablets are unsuitable for splitting because they lack score lines or have enteric/modified release coatings that are destroyed during splitting, impairing medication safety and effectiveness 2.
Computerized decision support systems have been implemented specifically to alert prescribers when dosage regimens demand inappropriate splitting of unscored tablets, demonstrating the clinical significance of this issue 2.
Proper Dosing Alternatives
If Dose Adjustment Is Needed
Switch to appropriate tablet strengths rather than splitting tablets 1.
Synjardy is available in multiple fixed-dose combinations including 5 mg/500 mg, 5 mg/1000 mg, 12.5 mg/500 mg, and 12.5 mg/1000 mg strengths 1.
Your prescriber can adjust your regimen by selecting a different tablet strength that matches your required dose without splitting 1.
Administration Instructions
Take Synjardy orally twice daily with meals to reduce gastrointestinal adverse reactions associated with the metformin component 1.
If you miss a dose, take it as soon as possible, but do not double up the next dose 1.
Common Pitfalls to Avoid
Never attempt to split Synjardy tablets even if you believe you need a lower dose—contact your healthcare provider to prescribe the appropriate tablet strength instead 1.
Do not confuse Synjardy with Synjardy XR (extended-release formulation), which also must not be split, crushed, dissolved, or chewed 1.
Splitting tablets can lead to inaccurate dosing of both empagliflozin and metformin, potentially compromising glycemic control and increasing adverse effects 2.