From the Research
The recommended dose of trimebutine for adults is 300 mg twice daily, as this dosage has been shown to be effective in treating functional gastrointestinal disorders with significant improvement in symptoms. This dosage is based on the most recent and highest quality study available, which demonstrated the efficacy of trimebutine in treating functional gastrointestinal disorders 1. The study found that trimebutine, prescribed at a dose of 300 mg twice daily for 28 days, resulted in a significant decrease in the severity of symptoms such as abdominal pain, epigastric pain, and biliary pain, with 74.73% of patients experiencing a significant decrease in the severity of abdominal pain after treatment. Key points to consider when prescribing trimebutine include:
- The medication should be taken orally, twice daily
- Treatment duration may vary depending on the condition being treated, but typically ranges from 2-4 weeks for acute symptoms of irritable bowel syndrome or functional gastrointestinal disorders
- Trimebutine works as a regulator of gastrointestinal motility by acting on peripheral mu, kappa, and delta opiate receptors, helping to normalize gut function whether it's hyperactive or hypoactive
- Common side effects may include mild gastrointestinal discomfort, dizziness, and skin reactions
- The medication should be used with caution in pregnant women, nursing mothers, and patients with severe liver or kidney impairment
- If symptoms persist beyond the initial treatment period, medical reassessment is recommended. It's worth noting that other studies have used different dosages, such as 200 mg three times daily 2, 3, 4 or 150 mg three times a day 5, but the most recent and highest quality study supports the use of 300 mg twice daily 1.