Ascoril LS Syrup Adult Dosage
The standard adult dosage of Ascoril LS syrup is 10 mL three times daily (total 30 mL per day), taken for up to 2 weeks for the treatment of productive cough associated with acute bronchitis or lower respiratory tract infections. 1
Standard Dosing Regimen
- 10 mL administered three times daily is the established adult dose for Ascoril formulations containing levosalbutamol as the bronchodilator component 1
- Treatment duration typically ranges from 7 to 14 days, with most patients showing significant improvement within the first week 1
- The formulation should be taken at regular intervals throughout the day to maintain therapeutic bronchodilation and mucolytic effects 1
Clinical Context and Efficacy
- Ascoril LS is primarily indicated for productive cough with difficulty in sputum expectoration in conditions such as acute bronchitis, lower respiratory tract infections (LRTI), acute exacerbations of chronic bronchitis (AECB), and bronchial asthma 2
- Clinical studies demonstrate that most patients report good therapeutic effect within 1 day of initiating treatment 3
- The combination formulation (containing levosalbutamol, bromhexine, and guaifenesin) showed efficacy in 69.7% of LRTI cases, 14.8% of AECB cases, and 8.5% of bronchial asthma cases 2
Safety Profile and Monitoring
- Common side effects are mild and transient, including tremor (1%), palpitations (0.9%), and vomiting (0.7%) 2
- The formulation is well tolerated with adverse reactions requiring treatment discontinuation occurring in less than 0.1% of cases 2
- No routine laboratory monitoring is required for short-term use (up to 2 weeks) 3
Important Clinical Considerations
- Levosalbutamol 0.625 mg is at least as effective as racemic salbutamol 2.5 mg but without the potential adverse effects of the therapeutically inactive (S)-enantiomer 4
- The bronchodilator component reduces cough sensitivity and promotes clearance of secretions while reducing inflammatory mediator release 2
- Antibiotics should be co-prescribed when purulent sputum is present, indicating bacterial infection 2
- Treatment should not exceed the recommended duration without medical reassessment, as prolonged use of bronchodilators may lead to tolerance 4