From the Research
Monjaro (tirzepatide) can cause side effects, including nausea, vomiting, diarrhea, and abdominal pain, as reported in the most recent study 1. The side effects of Monjaro are primarily gastrointestinal in nature and may also include decreased appetite, constipation, upper abdominal discomfort, and injection site reactions.
- Common side effects:
- Nausea
- Vomiting
- Diarrhea
- Decreased appetite
- Constipation
- Upper abdominal discomfort
- Abdominal pain
- Less common but more serious side effects:
- Pancreatitis
- Gallbladder problems
- Hypoglycemia (especially when used with insulin or insulin secretagogues)
- Potential thyroid tumors (based on animal studies) According to the study 1, the risk of side effects may increase with higher doses, which is why Monjaro treatment typically starts at a lower dose (2.5 mg once weekly) and gradually increases over time. If experiencing severe or persistent side effects, patients should contact their healthcare provider rather than discontinuing the medication abruptly, as most side effects are manageable with proper medical supervision and may be outweighed by the benefits of improved blood sugar control and potential weight loss for those with type 2 diabetes 1.