From the FDA Drug Label
2.3 Dosage for Treatment of ADHD The recommended starting dosage in adults and pediatric patients 6 years and older is 30 mg once daily in the morning. Dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to maximum recommended dosage of 70 mg once daily
2.4 Dosage for Treatment of Moderate to Severe BED in Adults The recommended starting dosage in adults is 30 mg once daily to be titrated in increments of 20 mg at approximately weekly intervals to achieve the recommended target dose of 50 mg to 70 mg once daily. The maximum recommended dosage is 70 mg once daily
The maximum dose of Vyvanse per day is 70 mg once daily 1.
- For ADHD, the maximum recommended dosage is 70 mg once daily.
- For Moderate to Severe BED in adults, the maximum recommended dosage is also 70 mg once daily. However, in patients with severe renal impairment, the maximum dosage should not exceed 50 mg once daily, and in patients with end stage renal disease, the maximum recommended dosage is 30 mg once daily 1.
From the Research
The maximum recommended daily dose of Vyvanse (lisdexamfetamine dimesylate) for adults is 70 mg per day, and for children with ADHD aged 6-17, the maximum dose is also 70 mg daily. This dosage limit is established to balance therapeutic benefits while minimizing the risk of side effects such as increased blood pressure, heart rate, insomnia, and the potential for dependence, as supported by studies such as 2 and 3. Treatment typically starts at a lower dose (30 mg for adults and children) and may be gradually increased by 10-20 mg increments at weekly intervals until the optimal response is achieved. Vyvanse should be taken once daily in the morning, with or without food. Taking it later in the day should be avoided as it may cause insomnia. Some patients may achieve optimal symptom control at lower doses, and the goal should always be to find the lowest effective dose. If 70 mg does not provide adequate symptom control, healthcare providers should reassess the diagnosis or consider alternative treatments rather than exceeding this maximum recommended dose.
Key points to consider when prescribing Vyvanse include:
- Starting with a lower dose and gradually increasing as needed
- Monitoring for side effects and adjusting the dose accordingly
- Considering alternative treatments if the maximum dose is not effective
- Being aware of the potential for dependence and abuse
It's also important to note that the efficacy and safety of Vyvanse have been demonstrated in several studies, including 4 and 5, which support its use as a treatment option for ADHD in adults and children. However, as with any medication, it's crucial to weigh the benefits and risks and make informed decisions based on individual patient needs.