From the Research
After a complete abortion, beta human chorionic gonadotropin (β-hCG) levels typically decline by approximately 50% within 24 hours, as supported by the most recent and highest quality study 1. This decline is consistent with the expected physiological response to the removal of trophoblastic tissue.
- The rate of decline can vary based on individual factors such as metabolism and renal clearance, but a decline of at least 50% within 24 hours is generally expected after a complete abortion.
- The study by 1 found that median hCG declines were 72.9% by day 1,87.6% by day 2, and 92.8% by day 3, confirming that a significant decline in β-hCG levels occurs within the first 24 hours after a complete abortion.
- It is essential to monitor β-hCG levels after an abortion to ensure that the levels are declining as expected, and to rule out any potential complications such as retained products of conception or gestational trophoblastic disease.
- Serial β-hCG measurements are recommended at 48-hour intervals until a significant decline is established, then weekly until levels return to non-pregnant range, as supported by the study 2.
- Persistent or rising β-hCG levels after abortion may indicate a complication, and further evaluation and management may be necessary.