From the Research
There are no significant known interactions between Fosamax (alendronate) and modafinil that would prevent taking these medications together, but recent evidence suggests that modafinil may have a negative impact on bone health, particularly in young individuals 1. However, timing of administration is important. Fosamax should be taken first thing in the morning with plain water, at least 30 minutes before any other medications, food, or beverages to ensure proper absorption. After taking Fosamax, you should remain upright (sitting or standing) for at least 30 minutes. Modafinil should be taken separately, typically in the morning, with or without food. The medications work through different mechanisms - Fosamax is a bisphosphonate that prevents bone breakdown and treats osteoporosis, while modafinil is a wakefulness-promoting agent that affects brain chemicals to reduce excessive sleepiness. Some key points to consider when taking these medications together include:
- The potential for modafinil to cause high turnover bone loss, particularly in young individuals 1
- The importance of monitoring bone health and adjusting treatment as needed
- The need to inform your healthcare provider about all medications you're taking, including over-the-counter drugs and supplements, to monitor for any potential individual-specific interactions or side effects
- The fact that modafinil may not be superior to placebo in improving fatigue in certain conditions, such as multiple sclerosis 2
- The potential for modafinil to cause side effects, such as decreased appetite and insomnia, particularly in children and adolescents with ADHD 3 While no major interactions exist between these specific medications, it's always advisable to inform your healthcare provider about all medications you're taking, including over-the-counter drugs and supplements, to monitor for any potential individual-specific interactions or side effects. Recent studies have highlighted the need for further research into the long-term effects of modafinil on bone health and other aspects of health 4. In terms of clinical practice, the results of these studies should be interpreted with caution, and patients should be closely monitored for any potential adverse effects. Overall, the decision to take Fosamax and modafinil together should be made on a case-by-case basis, taking into account the individual patient's needs and medical history.