What are the brand and generic names of oxycodone (oxycondone hydrochloride) HCl (hydrochloride)?

Brand and Generic Names of Oxycodone Hydrochloride

Oxycodone hydrochloride is the generic name, and it is marketed under multiple brand names including OxyContin (extended-release), OxyIR, Percolone, Roxicodone (immediate-release), and in combination products such as Percodan and Percocet (with acetaminophen). 1, 2

Generic Name

• Oxycodone hydrochloride (oxycodone HCl) is the official generic pharmaceutical name 2
• The chemical name is 4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride 2
• It is a white, odorless crystalline powder derived from the opium alkaloid thebaine 2

Brand Names - Extended-Release Formulations

• OxyContin is the most widely recognized brand name for controlled-release/extended-release oxycodone hydrochloride 1, 3, 4
• OxyContin is available in 10 mg, 20 mg, 40 mg, and 80 mg tablets designed for twice-daily administration 4, 5
• This formulation provides 12-hour duration of action 4

Brand Names - Immediate-Release Formulations

• OxyIR (immediate-release oxycodone) 1
• Percolone 1
• Roxicodone 1
• OxyNorm is available as capsules and oral solution for immediate-release administration 4

Combination Products

• Percodan contains oxycodone in combination with aspirin 1
• Percocet contains oxycodone combined with acetaminophen 1
• These combination products require monitoring of the non-opioid component (acetaminophen must be monitored for safe limits to avoid hepatic toxicity) 1

Clinical Context

• Oxycodone is a semi-synthetic opioid with agonist activity at mu, delta, and kappa opioid receptors 1, 4
• It is approximately 1.5 times more potent than morphine on a milligram-to-milligram basis 1, 6
• Oral bioavailability ranges from 60-87%, significantly higher than morphine 4, 7