From the Research
Estradiol Levels in Women
- Estradiol levels can vary depending on the stage of the menstrual cycle, age, and other factors 1, 2
- In premenopausal women, estradiol levels typically range from 31-2864 pmol/L during the menstrual cycle 1
- In postmenopausal women, estradiol levels are typically lower, with a reference interval of <26 pmol/L 1
Estradiol Levels with Progestin-Only Pill
- There is limited research on estradiol levels in women taking a progestin-only pill (Progestin) 3, 4
- However, studies on women taking oral estrogens suggest that serum estradiol levels can vary depending on the dose and formulation of the estrogen 4
- A study on postmenopausal women found that serum estradiol levels were not directly proportional to estrogen dose, and that conjugated estrogen 0.45 mg was equivalent to estradiol 1 mg in terms of serum concentration 4
Normal Estradiol Level Range
- The normal estradiol level range for a 35-year-old woman is not explicitly stated in the provided studies, but it can be estimated based on the reference intervals for premenopausal women 1, 2
- A study using LC-MS/MS method found that estradiol levels in premenopausal women ranged from 31-2864 pmol/L during the menstrual cycle, with a median level of 104-1742 pmol/L during the late follicular phase 1
- Another study found that estradiol levels in women of reproductive age ranged from <LOD to 100 pmol/L during mini-puberty, and increased with age and pubertal breast stage 2