Can I Use 100mg Three Times Daily (TID)?
Your question cannot be answered without knowing which medication you are asking about, as "100mg tid" is a dosing regimen that applies to many different drugs with vastly different safety profiles and indications.
Critical Information Needed
To provide a safe recommendation, I must know:
- Which specific medication you are referring to (e.g., eluxadoline, sildenafil, amitriptyline, metoclopramide, etc.)
- What condition you are treating
- Your medical history, particularly:
- Kidney function (creatinine clearance)
- Liver function
- Age
- Other medications you are taking
- Relevant comorbidities
Why This Matters
The same "100mg tid" dose can be:
- Appropriate and FDA-approved for some medications (e.g., eluxadoline 100mg twice daily for IBS-D is FDA-approved, though this is BID not TID) 1
- Excessive and dangerous for others (e.g., amitriptyline maximum is typically 100mg/day total, not per dose) 1
- Requires dose adjustment based on organ function (e.g., many medications require renal dose adjustment when creatinine clearance <30-50 mL/min) 1
Common Medications with 100mg Dosing
From the available evidence, medications that may use doses around 100mg include:
- Amitriptyline: 25-100mg/day (not per dose) for gastroparesis-related visceral pain 1
- Pregabalin: 100-300mg/day in divided doses for neuropathic pain 1
- Rimantadine: 100mg twice daily for influenza (not TID) 1
What You Should Do
Contact your prescribing physician or pharmacist immediately with your prescription bottle in hand to clarify:
- The exact medication name
- The intended dosing schedule
- Whether "100mg tid" was the actual instruction or if there was a transcription error
Do not start any medication at 100mg tid without explicit confirmation from your healthcare provider that this is the correct dose for your specific medication and medical situation.