From the Guidelines
Augmentin (Amoxicillin/Clavulanate) is recommended for sinusitis at a dose for 5 to 10 days.
Recommended Treatment
- The treatment should be initiated when symptoms of acute bacterial rhinosinusitis (ABRS) persist without improvement for at least 10 days beyond the onset of upper respiratory symptoms or worsen within 10 days after an initial improvement 1, 2.
- The specific dose of Augmentin is not specified in the provided evidence, but the general recommendation is to prescribe amoxicillin with or without clavulanate as first-line therapy for 5 to 10 days for most adults 1.
Diagnosis and Management
- Clinicians should distinguish presumed ABRS from viral upper respiratory infections and noninfectious conditions, and diagnose ABRS when symptoms or signs persist without improvement for at least 10 days or worsen within 10 days after an initial improvement 2.
- Watchful waiting without antibiotics may be offered for adults with uncomplicated ABRS, with assurance of follow-up to start antibiotic therapy if the patient’s condition fails to improve by 7 days after diagnosis or worsens at any time 2.
From the FDA Drug Label
For more severe infections and infections of the respiratory tract, the dose should be one 875 mg/125 mg amoxicillin and clavulanate potassium tablet every 12 hours or one 500 mg/125 mg amoxicillin and clavulanate potassium tablet every 8 hours. Table 1: Dosing in Patients Aged 12 weeks (3 months) and Older INFECTION | DOSING REGIMEN
| Every 12 hours | Every 8 hoursOtitis media, sinusitis, | 45 mg/kg/day | 40 mg/kg/day lower respiratory tract | | infections, and more | | severe infections | |
The recommended dose of Augmentin (Amoxicillin/Clavulanate) for sinusitis is:
- For patients aged 12 weeks (3 months) and older: 45 mg/kg/day every 12 hours or 40 mg/kg/day every 8 hours.
- For patients weighing 40 kg or more: one 875 mg/125 mg amoxicillin and clavulanate potassium tablet every 12 hours or one 500 mg/125 mg amoxicillin and clavulanate potassium tablet every 8 hours. The label does not specify after how long of symptoms the treatment should be initiated 3.
From the Research
Recommended Dose of Augmentin for Sinusitis
- The recommended dose of Augmentin (Amoxicillin/Clavulanate) for sinusitis is 875 mg of amoxicillin with 125 mg of clavulanate, taken twice a day for 7-10 days 4, 5.
- Some studies have investigated the use of high-dose amoxicillin/clavulanate, with doses of up to 2000 mg of amoxicillin per day, but the evidence suggests that this may not provide significant benefits over standard-dose therapy 4, 6.
Initiation of Augmentin Treatment
- The decision to initiate Augmentin treatment for sinusitis should be based on the presence of symptoms and signs of acute bacterial sinusitis, such as purulent nasal discharge and maxillary or frontal pain, which have persisted for at least 48-72 hours 7, 5.
- Treatment should be initiated as soon as possible after the diagnosis of acute bacterial sinusitis has been made, ideally within 3-5 days of the onset of symptoms 8.
Duration of Treatment
- The duration of Augmentin treatment for sinusitis is typically 7-10 days, but some studies have investigated the use of shorter treatment courses, such as 5 days 8.
- The choice of treatment duration should be based on the severity of symptoms, the presence of underlying medical conditions, and the response to treatment 8.