Geodon Generic
The generic name for Geodon is ziprasidone, available as ziprasidone hydrochloride for oral administration and ziprasidone mesylate for intramuscular injection. 1
Formulation Details
Oral formulation:
- Ziprasidone hydrochloride monohydrate is the active ingredient in oral capsules 1
- Available in 20 mg, 40 mg, 60 mg, and 80 mg capsule strengths 1
- Each capsule contains ziprasidone hydrochloride monohydrate equivalent to the labeled amount of ziprasidone free base 1
Intramuscular formulation:
- Ziprasidone mesylate is used for the IM formulation 2
- FDA-approved specifically for acute agitation in patients with schizophrenia 2
Chemical Structure
- The molecular weight of ziprasidone free base is 412.94 1
- Chemical name: 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one 1
- Empirical formula: C₂₁H₂₁ClN₄OS (free base) 1
- The hydrochloride monohydrate salt has a molecular weight of 467.42 1
Clinical Context
FDA-approved indications:
- Oral ziprasidone: treatment of schizophrenia and acute manic or mixed episodes associated with bipolar disorder 2
- Intramuscular ziprasidone: acute agitation in patients with schizophrenia 2
- In pediatric populations, ziprasidone is approved for acute mania in adults but not specifically approved for children, unlike lithium which has FDA approval down to age 12 years 3