Trelegy Daily Inhalation Frequency
Trelegy requires one inhalation once daily.
Dosing Regimen
Trelegy (fluticasone furoate/umeclidinium/vilanterol) is administered as one inhalation once daily using the ELLIPTA dry powder inhaler 1, 2.
The medication is delivered as a fixed-dose combination of 100/62.5/25 μg once-daily in the morning 3.
This once-daily dosing represents a key advantage over some alternative regimens that require twice-daily administration 1.
Clinical Context
The once-daily single-inhaler triple therapy (odSITT) formulation simplifies the treatment regimen for patients with moderate to severe COPD who require triple therapy 4, 5.
Studies confirm that the single-inhaler approach with once-daily dosing maintains non-inferiority to using two separate inhalers for the same medication components 3.
Better inhaler adherence with the once-daily regimen has been associated with more pronounced improvements in clinical outcomes 5.
Important Considerations
The ELLIPTA device delivers the medication through a single inhalation, making it straightforward for patients to use 6.
Patient education should emphasize the once-daily dosing schedule to optimize adherence and therapeutic outcomes 1.
The once-daily formulation was specifically designed to improve adherence compared to multiple-inhaler regimens requiring more frequent dosing 4.