Benadryl Safety During Breastfeeding
Benadryl (diphenhydramine) can be used during breastfeeding, but mothers must avoid co-sleeping with their infant while taking this sedating medication, and should use the lowest effective dose for the shortest duration.
Key Safety Considerations
Primary Precaution
- Mothers should not co-sleep with their infant while taking diphenhydramine, as this sedating medication can inhibit natural responsiveness to the baby during sleep 1
- The FDA label specifically advises breastfeeding mothers to ask a healthcare professional before use 2
General Compatibility
- All antihistamines, including first-generation agents like diphenhydramine, are considered safe to use during breastfeeding as minimal amounts are excreted in breast milk 3
- Low levels of antihistamines reach the breastfed infant, making them generally compatible with breastfeeding 4
Practical Recommendations
Dosing Strategy
- Take diphenhydramine at the lowest effective dose for the shortest duration 4
- Time medication administration just after breastfeeding or just before the infant's longest sleep period to minimize infant exposure 5
Monitoring for Adverse Effects
- Watch for paradoxical central nervous system stimulation in the infant, which can manifest as irritability or insomnia 4
- Marked drowsiness may occur in the mother, requiring caution when driving or operating machinery 2
Important Caveats
Combination Products
- Avoid combination cough and cold products that contain multiple active ingredients, as many contain alcohol, aspirin, or other components 4
- Use single-ingredient diphenhydramine products when possible 4
Alternative Considerations
- If diphenhydramine is being used for allergies, consider that triprolidine and pseudoephedrine are specifically designated as compatible with breastfeeding by the AAP and may be preferable first-line choices 4