Wegovy Dosing After 1.7mg
The next dose of Wegovy after 1.7mg is 2.4mg once weekly, which is the target maintenance dose for weight management.
Standard Wegovy Titration Schedule
The FDA-approved titration schedule for Wegovy (semaglutide for obesity) follows a specific escalation pattern to minimize gastrointestinal side effects while reaching the therapeutic dose 1, 2:
- 0.25mg once weekly for 4 weeks (initial dose)
- 0.5mg once weekly for 4 weeks
- 1.0mg once weekly for 4 weeks
- 1.7mg once weekly for 4 weeks
- 2.4mg once weekly (target maintenance dose) 3, 4
After completing 4 weeks at the 1.7mg dose, you should advance to 2.4mg once weekly, which is the final therapeutic dose for weight management 2, 4.
Why 2.4mg is the Target Dose
The STEP clinical trial program demonstrated that 2.4mg once weekly is the optimal dose for weight management, achieving mean weight loss of 14.9%-17.4% over 68 weeks 4. This dose showed:
- 69%-79% of participants achieved ≥10% weight loss (versus 12%-27% with placebo) 4
- 51%-64% achieved ≥15% weight loss (versus 5%-13% with placebo) 4
- Superior improvements in cardiometabolic risk factors compared to lower doses 2
Important Considerations
Gradual titration is essential - the 16-week escalation schedule allows gastrointestinal tolerance to develop and minimizes adverse events like nausea and diarrhea 5, 1.
Long-term use is necessary - participants who discontinued semaglutide regained significant weight (mean regain of 11.6% of lost weight after cessation), indicating lifelong treatment may be required 6.
If doses are missed: If you miss 3 or more consecutive doses at the 1.7mg level, consider restarting the titration schedule rather than jumping directly to 2.4mg 7, 5.
Common Pitfall to Avoid
Do not remain at 1.7mg indefinitely unless there are specific tolerability issues - this is a titration dose, not a maintenance dose 3. The clinical trial data supporting weight loss efficacy is based on reaching and maintaining the 2.4mg dose 2, 4.