Cerebrolysin Dosing Recommendations
For acute ischemic stroke and traumatic brain injury, the recommended dose of Cerebrolysin is 30-50 mL administered once daily via intravenous infusion over 60 minutes for 10-21 consecutive days, with treatment initiation within 24-72 hours of injury onset.
Standard Dosing Regimen
30 mL daily is the most commonly studied and effective dose for both stroke and traumatic brain injury, administered as a single intravenous infusion over 60 minutes 1, 2, 3
Treatment duration should be 10-21 consecutive days depending on injury severity, with more severe cases benefiting from the longer 21-day course 4, 2
Timing of initiation is critical: treatment should begin within 24-72 hours after stroke or TBI onset for optimal efficacy 1, 2, 3
Dose-Response Considerations
A dose-dependent effect exists, with higher doses (≥2.5 mL/kg in animal models, translating to 30-50 mL in humans) showing significantly better neurological outcomes compared to lower doses 5
The 50 mL daily dose may be considered for severe cases, as this higher dose was used successfully in multiple stroke trials without safety concerns 2
Doses below 30 mL daily have shown less consistent efficacy and should be avoided 5
Administration Protocol
Infusion method: Administer as a slow intravenous infusion over 60 minutes, not as a bolus injection 3
Dilution: Can be diluted in normal saline if needed for infusion 3
Frequency: Once daily administration is standard; divided dosing is not recommended 4, 1, 2
Severity-Specific Recommendations
Mild TBI: 30 mL daily for 10 days is effective for cognitive recovery 3
Moderate to severe TBI or stroke: 30-50 mL daily for 21 days shows improved outcomes at both 10 and 30 days post-injury 1, 2
Early treatment window: The 24-48 hour window for treatment initiation is associated with the best outcomes 1