Treatment of Worms in Feces
For most intestinal worm infections, treat with albendazole 400 mg orally as a single dose, which is effective for roundworm, hookworm, and pinworm. 1, 2
Diagnostic Approach First
Before treating, identify the specific worm type when possible:
- Visible worms in stool suggest roundworm (pink/white, earthworm-sized) or tapeworm (segments visible) 1, 3
- Concentrated stool microscopy is first-line for most helminths, with fecal PCR offering higher sensitivity when available 1, 2
- Travel history and exposure guide empirical treatment decisions 1, 2
Treatment by Specific Worm Type
Roundworm (Ascaris lumbricoides)
- Albendazole 400 mg PO single dose OR mebendazole 500 mg PO single dose OR ivermectin 200 μg/kg PO single dose 1
- All three options are equally effective 1
Hookworm (Ancylostoma/Necator)
- Albendazole 400 mg PO daily for 3 days (not single dose for hookworm) 2
- For severe disease with anemia, add prednisolone 40-60 mg once daily 2
Whipworm (Trichuris trichiura)
- Mebendazole 100 mg PO twice daily PLUS ivermectin 200 μg/kg once daily for 3 days 2
- This combination is necessary because whipworm has lower cure rates with single-agent therapy 4
Pinworm (Enterobius vermicularis)
- Albendazole 400 mg PO single dose OR mebendazole 100 mg PO single dose 2, 5
- Treat all household contacts simultaneously due to high contagiousness 2, 5
- For recurrent infections, use prolonged "pulse scheme" treatment for up to 16 weeks 5
Tapeworm (Taenia species)
Critical distinction for T. solium:
- Use niclosamide 2 g PO single dose for T. solium (pork tapeworm) 1
- Never use praziquantel for T. solium unless neurocysticercosis has been excluded, as antiparasitic agents can worsen cerebral edema 1
- For T. saginata (beef tapeworm): praziquantel 10 mg/kg PO single dose 1
- If species uncertain, use niclosamide 2 g PO single dose to avoid risk 1
Dwarf Tapeworm (Hymenolepis nana)
Schistosomiasis (if blood flukes suspected)
- Praziquantel 40 mg/kg PO single dose for S. mansoni 1
- Praziquantel 60 mg/kg PO in two divided doses for S. japonicum/mekongi or unknown Asian-Pacific species 1
Empirical Treatment Strategy
For patients from endemic areas with high pretest probability but negative stool tests:
- Give albendazole 400 mg PLUS ivermectin 200 μg/kg as a single combined dose 2
- This provides broad coverage for most intestinal helminths 2
Critical Safety Precautions
Before Using Ivermectin:
- Screen for Loa loa infection in patients from Central/West Africa before giving ivermectin to prevent severe encephalopathy 2
- Exclude Loa loa before ivermectin in any patient from endemic regions 1, 2
Albendazole Monitoring:
- Monitor for hepatotoxicity and leukopenia if treating for >14 days 1
- Elevated liver enzymes occur in up to 16% with prolonged therapy, requiring discontinuation in 3.8% 1
- Take albendazole with fatty meals to improve absorption 1
Special Populations:
- Do not use mebendazole in pregnancy 6
- Seek specialist advice for immunocompromised patients, children aged 12-24 months, and severe disease 2
Prevention of Reinfection
Essential hygiene measures to prevent reinfection:
- Wash hands and fingernails with soap frequently, especially before eating and after toilet use 1, 2, 6
- Wear shoes in endemic areas to prevent hookworm penetration through skin 1, 2
- Treat household contacts simultaneously for pinworm due to high contagiousness 2, 5
- For pinworm: wear tight underwear day and night, change daily, vacuum bedroom floors, wash bed linens after treatment 6
- Wash all fruits and vegetables thoroughly or cook them well 6
Common Pitfalls to Avoid
- Do not assume all "worms in stool" are the same - tapeworm requires different treatment than roundworm 1
- Do not use praziquantel empirically without excluding T. solium - risk of neurocysticercosis complications 1
- Do not give single-dose albendazole for hookworm - requires 3-day course unlike other helminths 2
- Do not forget to treat household contacts for pinworm - reinfection is nearly universal without this step 2, 5
- Stool microscopy for tapeworm carriers has low sensitivity; even multiple examinations may be negative 1