From the FDA Drug Label
DOSAGE AND ADMINISTRATION ... Dysmenorrhea: For the treatment of dysmenorrhea, beginning with the earliest onset of such pain, ibuprofen tablets should be given in a dose of 400 mg every 4 hours as necessary for the relief of pain. The dose for ibuprofen for menstrual cramps (dysmenorrhea) is 400 mg every 4 hours as necessary for the relief of pain 1.
From the Research
For menstrual cramps, the recommended dose of ibuprofen is 400 mg taken every 4-6 hours as needed, with a maximum daily dose of 1200 mg (3 tablets of 400 mg each). This dosage is based on the most recent and highest quality study available, which compared the efficacy of different treatments for primary dysmenorrhea 2. Although this particular study focused on interventions for heavy menstrual bleeding and pain associated with intrauterine-device use, it provides valuable insights into the management of menstrual cramps.
The mechanism of action of ibuprofen involves blocking prostaglandins, which are chemicals that cause inflammation, pain, and uterine contractions during menstruation 3. It is most effective when taken before pain becomes severe. To minimize stomach irritation, it is recommended to take ibuprofen with food or milk.
It is essential to note that if you have liver or kidney disease, stomach ulcers, heart conditions, or are taking blood thinners, you should consult with your healthcare provider before using ibuprofen 4, 5. Additionally, if 400 mg doesn't provide adequate relief, do not exceed the recommended dose; instead, speak with your healthcare provider about alternative treatments.
Some studies suggest that other treatments, such as naproxen sodium, may be more effective for some women 6, but ibuprofen remains a widely recommended and effective option for managing menstrual cramps. Always prioritize consulting with a healthcare provider for personalized advice on managing menstrual cramps.