What is the dosing frequency of ibuprofen (Advil) for a 16-month-old?

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Ibuprofen Dosing Frequency for a 16-Month-Old

Ibuprofen (Advil) can be given every 6-8 hours to a 16-month-old child, with a maximum of 3-4 doses in 24 hours. 1

Specific Dosing Parameters

  • The recommended dose is 10 mg/kg per administration, which can be given every 6-8 hours 1
  • The maximum total daily dose should not exceed 30-40 mg/kg per day 2
  • For practical administration, this translates to 3-4 doses maximum in a 24-hour period 1, 2

Critical Safety Considerations

  • Ibuprofen is only approved for infants older than 3 months of age with body weight above 5-6 kg 2
  • Special attention must be given to hydration status - ibuprofen should never be given to children with dehydration, diarrhea, or vomiting 2, 3
  • The oral route is strongly preferred over rectal administration in young infants due to erratic absorption with rectal formulations 2

Timing and Administration

  • Maximum fever reduction occurs 3-4 hours after administration 4
  • Each dose should be separated by at least 6 hours, though 8-hour intervals are acceptable 1
  • All dose times should be carefully recorded to avoid accidentally exceeding the maximum recommended daily dose 5

Important Clinical Caveats

  • Ibuprofen should not be used as a routine antipyretic except in rare cases - it is primarily indicated for inflammatory pain in children 3
  • Contraindications include: neonates, children with wheezing or persistent asthma, during varicella infection, or in patients sensitive to NSAIDs 3
  • For fever management in a 16-month-old, acetaminophen may be considered as an alternative, particularly if there are concerns about hydration or gastrointestinal symptoms 6

When to Seek Medical Attention

  • If fever or symptoms persist beyond 48-72 hours without improvement, medical evaluation is necessary 6
  • If the child shows decreased feeding, activity, or signs of dehydration, immediate medical assessment is required 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

A general overview of the use of ibuprofen in paediatrics.

International journal of clinical practice. Supplement, 2003

Guideline

Management of Respiratory Symptoms in Infants

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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