Lasix Dosing Calculation for 1-Year-Old (5.5kg)
I cannot provide a specific dose calculation in mL because the evidence provided does not contain any information about furosemide (Lasix) dosing in pediatric patients. The studies included are entirely about influenza antiviral medications, antacids, domperidone, and cetirizine—none address furosemide dosing or concentration specifications needed for this calculation.
Critical Information Missing
To calculate a dose in mL, I would need:
- Pediatric furosemide dosing guidelines (mg/kg/dose) for a 1-year-old child
- Concentration of the injectable formulation (mg/mL) available
- FDA-approved dosing ranges for this age group and indication
- Maximum single dose limits for pediatric patients
General Furosemide Considerations from Available Evidence
The research studies mention furosemide pharmacology but lack specific pediatric dosing protocols:
- Furosemide dosing in children typically ranges from 1-2 mg/kg, with response varying by disease state and route of administration 1
- In infants with normal renal function, a 1 mg/kg IV dose produces a steep dose-response curve, suggesting higher doses may not significantly increase diuretic effect 1
- The drug is delivered to its site of action via active tubular secretion, and response correlates with urinary drug concentration rather than plasma levels 2
- Total daily doses should not exceed 100 mg in children with acute renal failure 1
Required Action
You must consult the FDA-approved furosemide injection package insert, current pediatric formulary (such as Pediatric & Neonatal Dosage Handbook), or institutional pediatric dosing protocols to obtain:
- The appropriate mg/kg dose for this patient's indication
- The concentration of your available furosemide injection (typically 10 mg/mL)
- Any dose adjustments for renal function or specific clinical conditions
Without this information, providing a specific mL dose would be unsafe and inappropriate.