From the Research
Antiemetics and QT Interval Prolongation
- The following antiemetics have been studied for their potential to prolong the QT or QTc interval: + Ondansetron: Studies have shown that ondansetron does not significantly prolong the QTc interval 1, 2. + Dolasetron: Similar to ondansetron, dolasetron has been found not to lengthen the QT interval 1. + Domperidone: However, domperidone has been linked to QT interval prolongation 3, 4. + Metopimazine: There is no statistically significant association between metopimazine and QT interval prolongation 4. + Granisetron: Granisetron has been associated with a higher risk of cardiac adverse events related to QT interval prolongation 4.
Antiemetics That Do Not Prolong the QT Interval
- Based on the available evidence, the following antiemetics do not appear to prolong the QT or QTc interval: + Ondansetron 1, 2 + Dolasetron 1 + Metopimazine 4
- It is essential to note that individual patient responses may vary, and other factors can influence the risk of QT interval prolongation.
Studies with Relevant Findings
- A study published in the Mayo Clinic proceedings found that perioperative doses of ondansetron or dolasetron do not lengthen the QT interval 1.
- Another study published in The American journal of emergency medicine found no difference in the change in QTc interval at 4 hours post-study drug administration between a 24-mg bimodal-release ondansetron pill and placebo 2.