From the Guidelines
During H. pylori treatment, it's normal to experience temporary elevations in liver enzymes SGOT (AST) and SGPT (ALT), which are typically mild and resolve after completing the treatment regimen 1. These elevations occur because the antibiotics and other medications used to treat H. pylori are metabolized by the liver, placing temporary stress on liver function. Some key points to consider:
- Standard H. pylori therapy includes a proton pump inhibitor (like omeprazole 20mg twice daily) plus two antibiotics (such as amoxicillin 1000mg twice daily and clarithromycin 500mg twice daily) for 14 days 1.
- If you notice significant elevation in liver enzymes (more than 3 times the upper limit of normal), yellowing of skin or eyes, severe abdominal pain, or unusual fatigue, contact your healthcare provider immediately as medication adjustments may be needed.
- Regular monitoring of liver enzymes during treatment is recommended, especially for patients with pre-existing liver conditions.
- Most patients can complete the full treatment course without complications, but it's essential to follow the prescribed treatment regimen and attend follow-up appointments to ensure the infection is fully eradicated 1. Some important considerations:
- The treatment regimen may need to be adjusted based on individual patient factors, such as antibiotic resistance or underlying medical conditions 1.
- The use of antimicrobial stewardship can help optimize treatment regimens and improve patient outcomes 1.
- Further research is needed to develop more effective and targeted treatments for H. pylori infection, particularly in areas with high antibiotic resistance rates 1.
From the Research
SGOT and SGPT Levels While Taking H. Pylori Treatment
- The provided studies do not directly address the impact of H. pylori treatment on SGOT and SGPT levels 2, 3, 4, 5, 6.
- However, the studies discuss various treatment regimens for H. pylori eradication, including triple and quadruple therapies, and their efficacy and tolerability.
- Some studies mention the occurrence of adverse events, such as diarrhea, nausea, and vomiting, but do not specifically report on liver enzyme levels like SGOT and SGPT 3, 4, 6.
- It is essential to note that liver function tests, including SGOT and SGPT, are not explicitly mentioned in the provided studies as a concern or a monitored parameter during H. pylori treatment 2, 5.
- Therefore, there is no direct evidence from the provided studies to assist in answering the question about SGOT and SGPT levels while taking H. pylori treatment.