How many times a day can nystatin (antifungal medication) powder be applied?

Nystatin Powder Application Frequency

Nystatin powder should be applied to affected areas 2 or 3 times daily. 1

FDA-Approved Dosing

The FDA drug label explicitly states that nystatin topical powder should be applied to candidal lesions two or three times daily until healing is complete. 1 This applies to both adults and pediatric patients, including neonates. 1

Specific Application Guidelines

• For cutaneous candidiasis: Apply the powder 2-3 times daily directly to affected areas until resolution occurs. 1

• For fungal foot infections caused by Candida: Dust the powder on the feet 2-3 times daily AND apply inside all footwear to prevent reinfection. 1

• For very moist lesions: The topical dusting powder formulation is the preferred treatment option over creams or ointments. 1

Important Clinical Considerations

• Storage requirements: Keep at controlled room temperature 15-30°C (59-86°F) and avoid excessive heat above 40°C (104°F). 1

• Duration of therapy: Continue application until complete healing is achieved, not just until symptoms improve. 1

• Treatment failure: If no improvement occurs after 7 days of appropriate use, confirm the diagnosis with culture and consider switching to an alternative antifungal agent such as fluconazole. 2

When Nystatin Powder May Not Be Appropriate

• For moderate to severe oral candidiasis, systemic fluconazole (100-200 mg daily for 7-14 days) is superior to topical nystatin formulations. 2

• For systemic or invasive candidiasis, nystatin is not appropriate as it is not absorbed systemically; systemic antifungals are required. 2