Onset of Action for VIZZ (Aceclidine Ophthalmic Solution)
VIZZ begins working within 30 minutes of administration, with peak effect occurring at 3 hours post-dose, and maintains efficacy for up to 10 hours. 1
Detailed Onset Timeline
The FDA-approved labeling for VIZZ (aceclidine ophthalmic solution 1.44%) provides specific timing data from clinical trials:
- Initial onset: Effects begin at 30 minutes after instillation 1
- Peak effect: Maximum improvement occurs at 3 hours post-dose 1
- Duration of action: Therapeutic effect persists for up to 10 hours 1
In the pivotal CLARITY-1 and CLARITY-2 trials, 65-71% of participants achieved clinically significant improvement (gaining 3 or more lines in near visual acuity without losing distance vision) by 3 hours after the first dose. 1
Clinical Context
The rapid 30-minute onset makes VIZZ suitable for predictable daily use in presbyopia management. 1 The drug demonstrates consistent pharmacokinetics with minimal accumulation after repeat dosing—steady-state is achieved by Day 8 of once-daily administration. 1
Administration Considerations
- VIZZ is dosed as 2 drops per eye once daily (one drop followed by a second drop two minutes later) 1
- Contact lenses must be removed prior to instillation and should not be reinserted for 10 minutes 1
- If using multiple topical ophthalmic medications, separate administration by at least 5 minutes 1
Important Safety Note
Patients should be counseled that temporary dim or dark vision may occur, requiring caution with night driving and hazardous activities in poor illumination. 1 Temporary problems when changing focus between near and distant objects may also occur during the onset period. 1