Can hypercalcemia exacerbate osteoporosis?

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Last updated: February 13, 2025View editorial policy

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From the Research

Hypercalcemia and Osteoporosis

  • Hypercalcemia, or elevated calcium levels in the blood, can have a complex relationship with osteoporosis, a condition characterized by weakened bones 1, 2.
  • While calcium is essential for bone health, excessive calcium intake or hypercalcemia can lead to negative effects on bone density and increase the risk of osteoporosis 3, 4.

Effects of Hypercalcemia on Bone Health

  • Hypercalciuria, or high levels of calcium in the urine, is common in patients with osteoporosis and can be associated with both high and low bone turnover 5.
  • Studies have shown that hypercalciuria can predict loss of bone mineral density (BMD) at all sites, as well as an increased risk of fractures 3, 4.
  • Additionally, hypercalciuria has been linked to an increased risk of kidney stones and cardiovascular disease 3.

Relationship Between Hypercalcemia and Osteoporosis

  • The relationship between hypercalcemia and osteoporosis is complex, and more research is needed to fully understand the mechanisms involved 1, 2.
  • However, it is clear that maintaining normal urine calcium levels is beneficial for bone health, and that hypercalciuria can be a significant predictor of low bone mass and osteoporosis 3, 4.
  • Further studies are needed to examine the health effects of calcium supplementation and hypercalcemia on osteoporosis and other diseases 1, 2.

References

Research

Calcium and osteoporosis.

Nutrition (Burbank, Los Angeles County, Calif.), 1997

Research

Impact of urinary calcium excretion on kidney, bone, and cardiovascular systems in patients with bone biopsy proven osteoporosis: a longitudinal long-term follow-up study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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