From the Guidelines
Methylene blue supplements should not be used to increase energy due to their potential risks and lack of established benefits for this purpose. The primary use of methylene blue is for treating conditions like methemoglobinemia, and its effects on energy levels are not well-established 1. While methylene blue may improve mitochondrial function and increase cellular energy production, the evidence for its use as an energy supplement is limited and not well-studied. Typical dosages used in research range from 0.5-4 mg/kg body weight, but the potential benefits and risks of these dosages are not well-understood 1.
The use of methylene blue supplements can cause several side effects, including blue discoloration of urine and skin, digestive issues, and potentially dangerous interactions with certain medications, such as SSRIs and MAOIs, which can lead to serotonin syndrome 1. Additionally, methylene blue should be used with caution in patients with G6PD deficiency, renal failure, and pregnant women, due to concerns about teratogenicity and potential hemolysis 1.
Given the potential risks and lack of established benefits, it is recommended to consult with a healthcare provider before considering methylene blue supplements for energy, as they should not be used as a casual supplement due to their potent pharmacological effects and potential risks 1. The most recent and highest quality study 1 highlights the importance of caution when administering methylene blue, and its use should be limited to medically established indications, such as methemoglobinemia, under the guidance of a healthcare provider.
From the Research
Methylene Blue Supplements and Energy
- There is no direct evidence to suggest that methylene blue supplements increase energy 2, 3, 4, 5, 6.
- Methylene blue is primarily used as a treatment for methemoglobinemia, vasoplegic syndrome, and other medical conditions, rather than as an energy-boosting supplement 2, 3, 4.
- The available studies focus on the potential risks and adverse effects of methylene blue, such as hemolysis, methemoglobinemia, and serotoninergic toxicity, rather than its effects on energy levels 2, 3, 4, 6.
- One study suggests that methylene blue may interact with thyroid hormones, which could potentially affect energy levels, but this is not a direct investigation of energy-boosting effects 5.
Potential Risks and Interactions
- Methylene blue can cause serious adverse effects, including hemolysis, methemoglobinemia, and nausea, which could negatively impact energy levels 2, 3, 4, 6.
- Individuals with G6PD deficiency shouldn't use methylene blue as it may worsen hemolytic anemia 4, 6.
- The use of methylene blue as a supplement for energy-boosting purposes is not supported by the available evidence and may pose potential health risks 2, 3, 4, 5, 6.