What is the dose of lurasidone (Latuda)?

From the FDA Drug Label

1. 2 Depressive Episodes Associated with Bipolar I Disorder Adults The recommended starting dose of lurasidone hydrochloride tablets is 20 mg given once daily as monotherapy or as adjunctive therapy with lithium or valproate. Lurasidone hydrochloride tablets has been shown to be effective in a dose range of 20 mg per day to 120 mg per day as monotherapy or as adjunctive therapy with lithium or valproate The maximum recommended dose, as monotherapy or as adjunctive therapy with lithium or valproate, is 120 mg per day.

• The recommended dose of lurasidone (Latuda) is:
  • Starting dose: 20 mg per day
  • Effective dose range: 20 mg per day to 120 mg per day
  • Maximum recommended dose: 120 mg per day 1

From the Research

Dose of Lurasidone (Latuda)

• The recommended dose of lurasidone is 40-160 mg/day, administered once-daily with food 2, 3.
• The recommended starting dose is 40 mg/day, and initial dose titration is not required 2, 4.
• For bipolar depression, the dose range is 20-120 mg/day 3.
• Lurasidone should be taken with food, as absorption is halved on an empty stomach 5.

Administration and Pharmacokinetics

• Lurasidone is administered once daily, and its pharmacokinetic profile requires administration with food 3.
• Peak plasma concentrations are reached in 1-3 hours, with a mean elimination half-life of 18 hours 3.
• Lurasidone is approximately 99% bound to serum plasma proteins, and is principally metabolized by cytochrome P450 (CYP) 3A4 3.

Special Considerations

• Lurasidone has a favorable metabolic profile, with minimal weight gain and no clinically-meaningful alterations in glucose, lipids, or the electrocardiogram corrected QT (ECG QTc) interval 2, 6.
• Common adverse events include somnolence, akathisia, nausea, and parkinsonism 2, 4, 5, 6.