What is the recommended dose of ibuprofen (nonsteroidal anti-inflammatory drug) syrup for a 3-year-old child?

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Ibuprofen Syrup Dosing for a 3-Year-Old

For a 3-year-old child, administer ibuprofen syrup at 10 mg/kg per dose orally, given every 6-8 hours as needed, with a maximum daily dose of 40 mg/kg/day. 1, 2

Weight-Based Dosing Algorithm

  • Calculate the dose based on the child's weight: Use 10 mg/kg per dose as the standard recommendation 1, 2
  • Dosing interval: Administer every 6-8 hours (meaning 3-4 times daily maximum) 1, 2
  • Maximum daily dose: Do not exceed 40 mg/kg/day total 1
  • For children weighing more than 40 kg: Use adult dosing instead 2

Practical Dosing Example

If the 3-year-old weighs 15 kg:

  • Single dose = 10 mg/kg × 15 kg = 150 mg per dose
  • Can be given every 6-8 hours
  • Maximum daily = 40 mg/kg × 15 kg = 600 mg/day 1

Route of Administration

  • Oral syrup is the preferred formulation for consistent absorption and reliable therapeutic effect 2
  • Rectal administration should be avoided due to erratic absorption, particularly in young children 3

Safety Considerations for This Age Group

  • Ibuprofen is safe for children 3 months and older with body weight above 5-6 kg, provided special attention is given to hydration status 3
  • The 3-year-old age group falls well within the established safety profile for ibuprofen use 1, 2
  • Short-term use for fever and pain relief has been extensively studied and is considered safe 3

Common Pitfalls to Avoid

  • Dosing by age instead of weight: Parents who dose based on weight are significantly less likely to give incorrect doses (RR 0.71) 4
  • Exceeding maximum daily dose: Carefully track all doses given in 24 hours, as 11% of parents inadvertently exceed the maximum recommended number of doses 5
  • Consider providing parents with a dosing chart to record each administration time and amount to prevent accidental overdosing 5

Timing of Effect

  • Maximum fever reduction occurs 3-4 hours after administration 6
  • Ibuprofen has a longer duration of action compared to acetaminophen, supporting the 6-8 hour dosing interval 2, 6

Comparative Effectiveness

  • At the recommended 10 mg/kg dose, ibuprofen is equally effective or more effective than acetaminophen for fever and pain relief in children 6
  • The effective dose range demonstrated in clinical trials is 7.5-10 mg/kg, with 10 mg/kg being the standard recommendation 6

References

Guideline

Dosis de Ibuprofeno Pediátrico

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Pediatric Acetaminophen and Ibuprofen Dosing Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Acetaminophen and ibuprofen dosing by parents.

Pediatric emergency care, 2000

Research

A general overview of the use of ibuprofen in paediatrics.

International journal of clinical practice. Supplement, 2003

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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