What is the diagnosis for a 16-month-old patient with a history of myringotomy, hand-foot-and-mouth disease, a single papular lesion, and chronic rhinorrhea, who is currently afebrile?

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Differential Diagnosis for 16-month-old Patient

  • Single most likely diagnosis
    • Hand-foot-and-mouth disease (HFMD): The patient was sent home from daycare for possible HFMD, and the mother reports a pimple-like area on her buttocks, which is consistent with the rash seen in HFMD. The patient's recent history of myringotomy and low-grade fever are also consistent with a viral illness like HFMD.
  • Other Likely diagnoses
    • Viral gastroenteritis: The patient's symptoms of chronic rhinorrhea and recent low-grade fever could be indicative of a viral gastrointestinal infection.
    • Common cold: The patient's symptoms of chronic rhinorrhea could be indicative of a common cold, especially given the recent history of myringotomy, which may have increased her susceptibility to upper respiratory infections.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Bacterial sepsis: Although the patient is afebrile, the recent history of myringotomy increases her risk of bacterial infections, and sepsis is a potentially life-threatening condition that must be considered.
    • Meningitis: The patient's recent history of myringotomy and symptoms of chronic rhinorrhea could be indicative of a more serious infection like meningitis, especially if the patient is not fully vaccinated.
  • Rare diagnoses
    • Scarlet fever: The patient's symptoms of a pimple-like rash and recent low-grade fever could be indicative of scarlet fever, although this is less likely given the absence of a characteristic sandpapery rash and strawberry tongue.
    • Kawasaki disease: The patient's symptoms of chronic rhinorrhea and recent low-grade fever could be indicative of Kawasaki disease, although this is less likely given the absence of other characteristic symptoms like conjunctivitis and cervical lymphadenopathy.

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