Does Lexapro Cause Thirst?
Yes, Lexapro (escitalopram) can cause increased thirst, particularly in children and adolescents, though this side effect is less commonly reported in adults.
Evidence from FDA Labeling
The FDA-approved drug label for escitalopram specifically lists increased thirst as a side effect observed in children and adolescents 1. The label states that "other side effects in children and adolescents include: increased thirst, abnormal increase in muscle movement or agitation, nose bleed, difficult urination, heavy menstrual periods, possible slowed growth rate and weight change" 1.
Clinical Context and Mechanism
While increased thirst is explicitly documented in pediatric populations, the mechanism may relate to:
Anticholinergic effects: SSRIs including escitalopram commonly cause dry mouth, which can lead to compensatory increased thirst 2. Dry mouth is listed among the common side effects in adults taking escitalopram 1.
Potential SIADH: Though rare, escitalopram has been associated with syndrome of inappropriate antidiuretic hormone (SIADH), which paradoxically can alter fluid balance and potentially affect thirst perception 3.
Common Side Effects Profile
The most frequently reported side effects of escitalopram in adults include 1:
- Nausea
- Dry mouth (which may trigger thirst)
- Sleepiness
- Dizziness
- Sweating
- Constipation
Clinical Recommendations
If you experience increased thirst while taking Lexapro:
- Monitor for other symptoms of dry mouth, which is a common anticholinergic side effect 1
- Stay adequately hydrated, but report persistent or severe thirst to your healthcare provider 1
- Be aware that in rare cases, significant changes in thirst combined with other symptoms could indicate SIADH, which requires medical evaluation 3
The side effect is generally mild and manageable, but any bothersome or persistent symptoms should be discussed with your prescribing healthcare provider 1.