Duvadilon (Isoxsuprine) Use in Pregnancy
I cannot provide specific guidance on the gestational age limit for Duvadilon (isoxsuprine) use in pregnancy because none of the provided evidence addresses this medication. The evidence exclusively covers ADHD medications (stimulants, atomoxetine), antidepressants (SSRIs, duloxetine), and antihypertensives—none of which are Duvadilon.
Critical Clarification Needed
Duvadilon (isoxsuprine) is a vasodilator and tocolytic agent, historically used to suppress preterm labor, which is entirely different from the medications discussed in the provided evidence.
What the Evidence Actually Covers
The provided studies discuss:
- ADHD medications in pregnancy including amphetamines, methylphenidate, atomoxetine, and other stimulants 1
- Antihypertensive agents such as hydralazine, labetalol, nifedipine, and methyldopa for pregnancy-related hypertension 1
- Antidepressants including SSRIs (sertraline) and SNRIs (duloxetine) for mood disorders 2, 3, 4, 5
General Tocolytic Principles (Not Specific to Duvadilon)
While the evidence discusses management of preterm labor indirectly, no specific gestational age cutoffs for isoxsuprine are provided 1.
Recommendation
You must consult:
- Current obstetric guidelines specifically addressing tocolytic agents
- Local formulary or drug information resources for isoxsuprine
- Manufacturer's prescribing information for Duvadilon
- An obstetrician or maternal-fetal medicine specialist for case-specific guidance
The evidence provided does not support making any recommendation about Duvadilon's use at any gestational age.