What is Eroxon Gel?
Eroxon is a topical erythromycin solution indicated for the treatment of acne vulgaris. 1
Primary Indication and Mechanism
Eroxon (erythromycin topical solution) is FDA-approved specifically for topical treatment of acne vulgaris. 1
Erythromycin functions as a topical antibiotic that reduces acne-causing bacteria (P. acnes) on the skin surface. 2, 3
Clinical Context and Treatment Guidelines
Role in Acne Management
Topical antibiotics like erythromycin should never be used as monotherapy for acne—they must always be combined with benzoyl peroxide to prevent bacterial resistance. 2, 3
The American Academy of Dermatology recommends topical antibiotics (including erythromycin) combined with benzoyl peroxide for mild to moderate inflammatory acne. 3
When used in combination with benzoyl peroxide, the recommended application frequency is twice daily for optimal efficacy. 2
Treatment Algorithm Position
For mild acne:
- First-line treatment is a topical retinoid (adapalene, tretinoin, or tazarotene) as monotherapy. 3
- Alternative treatment is benzoyl peroxide alone or combined with a topical antibiotic like erythromycin. 3
For moderate to severe acne:
- Topical combination therapy with retinoid + benzoyl peroxide ± topical antibiotic (such as erythromycin) is recommended. 3
Critical Clinical Pitfalls
Bacterial resistance is a major concern with topical antibiotics—erythromycin must be combined with benzoyl peroxide, which prevents resistance development. 2, 3
Unlike benzoyl peroxide (which has no reported bacterial resistance), topical antibiotics used alone will lead to resistant P. acnes strains. 2
Eroxon/erythromycin is distinct from metronidazole gel, which is not recommended for acne vulgaris but is FDA-approved for rosacea treatment instead. 3