Generic Name for Cymbalta
The generic name for Cymbalta is duloxetine. 1
Pharmacological Classification
- Duloxetine is classified as a selective serotonin and norepinephrine reuptake inhibitor (SNRI) 2, 1
- It is a balanced and potent inhibitor of both serotonin and noradrenaline (norepinephrine) transporters in the central nervous system 3, 4
- Duloxetine has weak dopamine transporter inhibition and low affinity for other neuronal receptors including alpha-adrenergic, histamine, muscarinic, and opioid receptors 3
FDA-Approved Indications
Duloxetine is approved for multiple clinical conditions 1:
- Major depressive disorder (MDD) in adults 1, 4
- Generalized anxiety disorder (GAD) in adults and pediatric patients 7 years and older 1, 3
- Diabetic peripheral neuropathic pain (DPNP) 5, 1
- Fibromyalgia in adults and adolescents 13 years and older 1
- Chronic musculoskeletal pain, including chronic low back pain and osteoarthritis 2, 1
Standard Dosing
- The typical starting dose is 30 mg once daily for one week, then increased to 60 mg once daily 2
- The target maintenance dose for most indications is 60 mg once daily 2, 1
- The maximum approved dose is 120 mg/day (administered as 60 mg twice daily) 2, 1
- For diabetic peripheral neuropathy specifically, the FDA-approved dosing range is 60-120 mg daily 5, 1
Key Pharmacokinetic Properties
- Duloxetine has a mean elimination half-life of approximately 12 hours 3, 6
- It is extensively metabolized in the liver primarily by CYP1A2 and CYP2D6 enzymes 5, 3
- Duloxetine is a moderate inhibitor of CYP2D6, which can affect metabolism of other drugs 2, 3
- Steady-state plasma concentrations are typically reached by day 3 of administration 3